apalutamide will decrease the extent or effect of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with medicines that happen to be CYP2C19 substrates may result in decrease publicity to these prescription drugs.Infants born to moms using benzodiazepines